Han Zhu, PhD (he/him)
Principal Investigator
Dr. Zhu is an Assistant Professor in the Department of Pediatrics, Section of Developmental Biology, at the University of Colorado Anschutz Medical Campus, with a joint appointment at the Barbara Davis Center for Diabetes. He leads the Zhu Lab, which focuses on understanding how human pancreatic β-cells develop, mature, and function, with the long-term goal of improving cell-based therapies for type 1 diabetes (T1D).
Dr. Zhu’s research uses human stem cell models to study the biological processes that guide β-cell formation and identity. A major emphasis of his work is addressing key challenges that limit the effectiveness of stem-cell-derived islets, including inaccurate beta cell lineage progression and incomplete β-cell maturation. By integrating developmental biology with translational research, his laboratory aims to generate more functional and reliable β-cells for diabetes therapy.
Dr. Zhu completed his postdoctoral training at the University of California, San Diego, where he studied the molecular basis of human β-cell development and dysfunction in diabetes. His research has been supported by funding from the National Institutes of Health. He has authored peer-reviewed publications in leading journals in the fields of stem cell biology, developmental biology, and diabetes research.
Xiuqing Wei, PhD (she/her)
Research Instructor
Xiuqing received her Ph.D. from the Hong Kong University of Science and Technology (HKUST). She joined Dr. Puri’s laboratory at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla as a postdoctoral fellow in August 2020. Driven by her interest in understanding human diseases, particularly diabetes, and improving patient quality of life, she became a Research Instructor in the Zhu Lab in September 2024. Her research focuses on pancreatic β-cell dysfunction in Type 1 diabetes (T1D), using human induced pluripotent stem cells (iPSCs), CRISPR-based genome editing, and integrated transcriptomic and epigenetic profiling.
Jinxing Ma, PhD (she/her)
Postdoctoral Fellow
Jinxing obtained her Ph.D. from Peking University in 2020, with formal training in neurobiology. Her doctoral research focused on central nervous system plasticity following peripheral nerve injury. From 2020 to 2024, she conducted neuroscience-related research in orthopedics, investigating neural mechanisms underlying orthopedic diseases and injuries. She is a clinician-scientist with a background in orthopedic surgery, with extensive clinical experience and three years of standardized residency training. Her research interests center on clinically relevant disease mechanisms and the establishment of cellular networks during islet development, which share important similarities with neuronal network organization. She is skilled in patch-clamp electrophysiology, imaging, behavioral assays, and small animal surgical techniques.